报告题目：Gold Clusters for Tumor Analysis
报告时间：2019年3月25号上午9点30分
报告地点：新葡的京集团35222vipD912会议室
高学云973首席科学家、国家杰青
工作经历：2017-北京工业大学环能学院,教授2007-2017，中科院高能物理研究所，中科院重点实验室“纳米生物效应与纳米安全实验室”副主任，研究员1992-2000，中国科学技术大学，助教/讲师
基础研究：近10多年来，聚焦于新的生物分析成像方法，精准检测生物体内的早期癌症病变指标，为疾病早期诊断和早期治疗提供新的分析方法。申请人从仪器系统、理论模拟、活细胞/活体分析成像的研究出发，建立了较完整的、新颖的生物分析方法体系。实现了活细胞和活体内多种功能分子的灵敏检测，为重大疾病的早诊和早治提供了新的分析和诊断方法。主要学术成绩如下： （a）搭建仪器硬件：搭建了具有时间分辨和空间分辨的活细胞荧光成像系统，实现了细胞内分子的原位观测；将生物质谱技术、X-ray技术、核定量级术与活细胞、活体成像系统结合，实现了细胞、活体内分子的定量检测。（b）构建成像探针：构建了标记细胞、活体内分子的专利探针库，包括系列荧光探针、系列质谱探针、核成像佐剂。实现了细胞内、活体多种功能分子的特异荧光标记、特异核标记、特异质谱标记。同时，验证了系列探针的生物安全性。（c）实现理论模拟：从理论上揭示了探针具有荧光、磁、电信号的物理机制。从理论上刻画了了探针特异结合细胞、活体内分子的动力学过程。（d）建立分析方法：利用活细胞、活体成像系统、质谱技术、核分析技术、纳米探针和核成像佐剂，建立了活细胞、活体内多种分子的原位荧光标记、核标记、质谱定量的系列生物分析方法。为癌症的早诊早治提供了新的方法。目前，聚焦于国家大科学光源装置，发展前沿的生物分析方法，为生物基础研究和临床疾病诊断，提供创新的生物分析方法学。近10年，发表SCI论文百余篇，包括化学和材料领域的期刊，如：Acc. Chem. Res.；JACS；Adv. Mater.等。应邀为化学和材料领域的期刊撰写评论综述，如Acc. Chem. Res., Adv. Mater., Small，CRC Handbook学术工具书撰写纳米专题。
应用研究：获1项省科学技术一等奖。获2项美国发明专利授权（US8383919 B2；US8445026B2）。获1项中国发明专利授权（ZL97107038.5），主持实现该专利技术的工业化生产放大和定型生产，完成卫生部产品申报并获得批文1998（134号；功能：提高免疫），并于2000年实现该产品的市场化。
报告摘要：
Bridging the gap between atoms and nanoparticles, noble metal clusters with atomic precision continue to attract considerable attention due to their important applications in catalysis, engergy transformation, biosensing and biomedicine. Among them, peptide-protected Au Cs (peptid-Au Cs) possesses a great deal of exceptional advantages such as sub-nanometer dimension, high photostability, good biocompatibility, accurate chemical formula and specifically protein targeting capacity. Under mild conditions, multifunctional peptides containing metal capture, reactive and targeting groups are rationally designed and elaborately synthesized to fabricate atomically precise peptid-Au Cs. We focus on the recent advances on potential theranostic fields by introducing the rising progress of peptide-Au Cs for biological imaging, biological analysis and therapeutic applications for advanced tumor theranostics. The interactions between Au Cs and biological systems as well as potential mechanisms are also our concerned theme. We expect that the rapidly growing interest in Au Cs-based theranostic applications will attract broader concerns across various disciplines.
研究文章：
1. Xueyun Gao, Gengmei Xing, Yanlian Yang, Xiaoli Shi, Ru Liu, Weiguo Chu, Long Jing, Feng Zhao, Chang Ye, Hui Yuan, Xiaohong Fang, Chen Wang, Yuliang Zhao. Detection of Trace Hg(2+) via Induced Circular Dichroism of DNA Wrapped Around Single-Walled Carbon Nanotubes. JACS. 130 (2008) 9190.
2. Taisen Zuo, Zhipeng Sun, Yuliang Zhao, Xiaoming Jiang, Xueyun Gao. The big red shift of photoluminescence of Mn dopants in strained CdS: a case study of Mn-doped MnS-CdS heteronanostructures. JACS. 132 (2010) 6618.
3. Xueyun Gao, Lide Zhang. Hollow sphere selenium nanoparticles: Their in-vitro anti hydroxyl radical effect. Advanced Materials. 14 (2002) 290-293.
4. Xueyun Gao, Ramin Djalali, Amit Haboosheh, Jacopo Samson, Nurxat Nuraje, Hiroshi Matsui. Peptide Nanotubes: Simple Separation Using Size‐Exclusion Columns and Use as Templates for Fabricating One‐Dimensional Single Chains of Au Nanoparticles. Advanced Materials. 17, (2005) 1753-1757.
5. Xueyun Gao, Hiroshi Matsui. Peptide-Based Nanotubes and Their Applications in Bionanotechnology. Advanced Materials. 17, (2005) 2037-2050.
6. Xueyun Gao, Lingtao Yu, Robert MacCuspie, and Hiroshi Matsui. Controlled Growth of Se Nanoparticles on Ag Nanoparticles in Different Ratios. Advanced Materials.
7, (2005) 426-429. 7. Xueyun Gao, Gengmei Xing, Weiguo Chu, Xingjie Liang, Yuliang Zhao, Long Jing, Hui Yuan, Yanyan Cui, Jinquan Dong. The Growth of Complex Nanostructures: Synergism of Dipolar Force and Stacking‐Defects in Anisotropic Self‐Assembly. Advanced Materials. 20 (2008) 1794-1798.
8. Ping Huang, Huarui Zhu, Long Jing, Yuliang Zhao, Xueyun Gao. Graphene covalently binding aryl groups: conductivity increases rather than decreases. ACS Nano. 5 (2011) 7945-7949.
9. Ru Liu, Zhong Chen, Yaling Wang, Yanyan Cui, Huarui Zhu, Ping Huang, Wei Li, Yuliang Zhao, Ye Tao, Xueyun Gao. Nanoprobes: quantitatively detecting the femtogram level of arsenite ions in live cells. ACS Nano. 5, (2011) 5560-5565.
10. Ping Huang, Long Jing, Huarui Zhu, Xueyun Gao. Diazonium Functionalized Graphene: Microstructure, Electric, and Magnetic Properties. Accounts of Chemical Research. 46, (2013), 43-52.
